One way might be . . .
One idea is to take each region in turn; you might want to begin with the NE because it was mostly settled first. Begin by looking at the geographical features. Give the students a map of the regions with a list (states, capitals, major cities, important landmarks, rivers, ocean, mountains, etc.) Using an atlas map have them label on each thing on the list. Be sure they know the characteristic that determines this region. Then take a look at the early history. There are many sites on internet to supplement this. Finally, look at how people in the region make a living today. I noticed that Harcourt's web site has a section on their Regions textbook. Probably others do to. Students could each choose a state and become an expert on their state, presenting some sort of activity on their state - perhaps a "float" for a parade, a poster, a special food to sample.
It's so much easier to teach using a good textbook, isn't it? They are just hard to find.